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HRID1720383

反应详情

EQUATION

反应方程式

HRID 1720383 反应方程式

REACTANTS

反应物

2
Isopropylamine 分子结构式
HCID6363

Isopropylamine

C3H9N

2-[4-Chloro-5-(cyclopentyloxy)-2-fluorophenyl]-4,5,6,7-tetrahydro-1H-isoindole-1,3(2H)-dione 分子结构式
HCID15279390

2-[4-Chloro-5-(cyclopentyloxy)-2-fluorophenyl]-4,5,6,7-tetrahydro-1H-isoindole-1,3(2H)-dione

C19H19ClFNO3

PRODUCTS

产物

1
HCID 19425288 分子结构式
HCID19425288

未命名化合物

收率 60.2%

AUXILIARIES

试剂、催化剂与溶剂

1
Benzene 分子结构式
溶剂HCID241

Benzene

C6H6

PROCEDURE

实验过程

N-(2-Fluoro-4-chloro-5-cyclopentyloxyphenyl)-3,4,5,6-tetrahydrophthalimide (1.00 g, 2.75 mmol), isopropylamine (0.600 g, 10.2 mmol) and benzene (25 ml) as a solvent were placed into a round bottom flask (50 cc) and stirred overnight at room temperature. After completion of the reaction, the precipitated crystals were isolated by filtration. The crystals were washed with hexane and dried to obtain N-(2-fluoro-4-chloro-5-cyclopentyloxyphenyl)-N'-isopropyl-3,4,5,6-tetrahydrophthalamide as white crystals (0.700 g, 60.0% yield).

WORKUP

后处理

  1. customAfter completion of the reaction
  2. customthe precipitated crystals were isolated by filtration
  3. washThe crystals were washed with hexane
  4. customdried