4-Hydroxypyrrolidine → 2-[2-[5-chloro-7-(cyclopentylamino)-1H-indol-2-yl]-4,5-dihydro-1,3-thiazol-4-yl]-1-(3-hydroxypyrrolidin-1-yl)ethanone

HRID 172044Notes

Reaction equation

HRID 172044 reaction equation
[Cl:1][c:2]1[cH:3][c:4]2[cH:5][c:6]([C:17]3=[N:21][CH:20]([CH2:22][C:23](=[O:24])[OH:25])[CH2:19][S:18]3)[nH:7][c:8]2[c:9]([NH:11][CH:12]2[CH2:13][CH2:14][CH2:15][CH2:16]2)[cH:10]1.[NH:26]1[CH2:27][CH:28]([OH:31])[CH2:29][CH2:30]1>>[Cl:1][c:2]1[cH:3][c:4]2[cH:5][c:6]([C:17]3=[N:21][CH:20]([CH2:22][C:23](=[O:25])[N:26]4[CH2:27][CH:28]([OH:31])[CH2:29][CH2:30]4)[CH2:19][S:18]3)[nH:7][c:8]2[c:9]([NH:11][CH:12]2[CH2:13][CH2:14][CH2:15][CH2:16]2)[cH:10]1

Participants

3

Reactant 2

HCID 982104-HydroxypyrrolidineHCID 669741432-[2-[5-chloro-7-(cyclopentylamino)-1H-indol-2-yl]-4,5-dihydro-1,3-thiazol-4-yl]acetic acid

Product 1

HCID 669742562-[2-[5-chloro-7-(cyclopentylamino)-1H-indol-2-yl]-4,5-dihydro-1,3-thiazol-4-yl]-1-(3-hydroxypyrrolidin-1-yl)ethanone

Sources & evidence

ORD record
ord-02707916717c49e1aa791ea4924b049f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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