Sodium Hydroxide → HCID 178453624, compound

Participants

Reaction Steps

63.6 ml of an N aqueous NaOH solution and 1.28 g of MgO are introduced, at 0° C., into 50 ml of dioxane containing 5 g of trans-4-(aminomethyl)cyclohexylcarboxylic acid, followed, slowly, by 6.94 g of di(t-butyl)carbonate in solution in 20 ml of dioxane. After 20 hours at room temperature, the mixture is filtered, the solvent is removed and the residue is taken up in 100 ml of H2O and the aqueous phase is washed with (C2H5)2O before acidifying it up to pH 2 by addition of KHSO)4 ; it is then extracted in CH3COOC2H5 to yield 7.3 g of trans-N-(t-butoxycarbonyl)-4-(aminomethyl)cyclohexylcarboxylic acid which melts at 125° C.

Provenance & Evidence