HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2S)-1-(N-Benzyloxycarbonyl-L-prolyl)-2-[l-hydroxy-2-(4-methoxyphenoxy)ethyl]pyrrolidine → (2S)-1-(N-Benzyloxycarbonyl-L-prolyl)-2-[(4-methoxyphenoxy)-acetyl]pyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2S)-1-(N-Benzyloxycarbonyl-L-prolyl)-2-[l-hydroxy-2-(4-methoxyphenoxy)ethyl]pyrrolidine | HCID 57161012 | — |
| Reactant | Dmso dcc | HCID 86749402 | — |
| Product | (2S)-1-(N-Benzyloxycarbonyl-L-prolyl)-2-[(4-methoxyphenoxy)-acetyl]pyrrolidine | HCID 70049382 | 99% |
Reaction Steps
(2S)-1-(N-Benzyloxycarbonyl-L-prolyl)-2-[l-hydroxy-2-(4-methoxyphenoxy)ethyl]pyrrolidine (10.94 g) was subjected to DMSO-DCC oxidation in the same manner as in Example 1, D) to give 10.78 g of the title compound (See Table 6).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05506256 |
| Source dataset | uspto-grants-1996_04 |
| ORD ID | ord-b6ae45869af84dd29b8b3c65e4c310ee |
| Source note | uspto-grants-1996_04 |