HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl isocyanate → N-Benzylaminocarbonyl-L-prolyl-L-proline benzyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl isocyanate | HCID 76639 | — |
| Reactant | Boc-prolylproline benzyl ester | HCID 13091041 | — |
| Reactant | 1,4-Dioxane hydrochloride | HCID 20443148 | — |
| Product | N-Benzylaminocarbonyl-L-prolyl-L-proline benzyl ester | HCID 54203628 | — |
Reaction Steps
N-(t-Butoxycarbonyl)-L-prolyl-L-proline benzyl ester (3.60 g) was treated with 4N hydrochloric acid/1,4-dioxane and then reacted with benzylisocyanate (1.2 ml) as in Example 21-B) to give 2.98 g of the title compound as crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05506256 |
| Source dataset | uspto-grants-1996_04 |
| ORD ID | ord-b84af5812abb4f50ab18d772935500d3 |
| Source note | uspto-grants-1996_04 |