HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-(-)-4-methoxyphenyl methyl sulfoxide → (2S)-1-(N-Benzylaminocarbonyl-L-prolyl)-2-{[(S)-4-methoxyphenylsulfinyl]acetyl}pyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-(-)-4-methoxyphenyl methyl sulfoxide | HCID 12072511 | — |
| Reactant | N-Benzylaminocarbonyl-L-prolyl-L-proline benzyl ester | HCID 54203628 | — |
| Product | (2S)-1-(N-Benzylaminocarbonyl-L-prolyl)-2-{[(S)-4-methoxyphenylsulfinyl]acetyl}pyrrolidine | HCID 53731509 | 27.6% |
Reaction Steps
By the same procedure as in Example 15-D) using N-benzylaminocarbonyl-L-prolyl-L-proline benzyl ester (2.00 g) and (S)-(-)-4-methoxyphenyl methyl sulfoxide (780 mg) as obtained in Example 15-C), there was obtained 629 mg of the title compound as colorless needles (See Table 7).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05506256 |
| Source dataset | uspto-grants-1996_04 |
| ORD ID | ord-bbf5c93b052c4134bc0b9397633af16b |
| Source note | uspto-grants-1996_04 |