Acetic Acid → HCID 22860068, compound

Participants

Reaction Steps

To a solution of (2S)-2-[4-(benzyloxy)phenoxyacetyl]-1-[N-(3-phenylpropionyl)-L-prolyl]pyrrolidine (1.44 g) in a mixture of methanol (50 ml), water (30 ml) and acetic acid (20 ml) was added Pd-Black (300 mg), and the mixutre was stirred at room temperature under hydrogen atmosphere for 4 hours. The reaction mixture was concentrated, and the concentrate was poured into saturated aqueous solution of sodium bicarbonate and extracted with ethyl acetate. The organic layer was washed with saturated aqueous solution of sodium bicarbonate and saturated brine, dried over anhydrous magnesium sulfate, and concentrated. The residue was purified by silica gel column chromatography (eluate: chloroform-methanol) to give 0.71 g of the title compound.

Provenance & Evidence