4-Fluorophenol → HCID 67771364, compound

HRID 1720514Notes

Reaction equation

HRID 1720514 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:12][CH2:11][CH2:10][C@H:9]1[CH:13]1[O:15][CH2:14]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[F:16][C:17]1[CH:22]=[CH:21][C:20]([OH:23])=[CH:19][CH:18]=1>>[C:1]([O:5][C:6]([N:8]1[CH2:12][CH2:11][CH2:10][C@H:9]1[CH:13]([OH:15])[CH2:14][O:23][C:20]1[CH:21]=[CH:22][C:17]([F:16])=[CH:18][CH:19]=1)=[O:7])([CH3:2])([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 97324-FluorophenolHCID 15297813tert-butyl (2S)-2-(oxiran-2-yl)pyrrolidine-1-carboxylate

Product 1

HCID 67771364HCID 67771364, compoundYield 62.6%

Procedure

By the same procedure as in Example 26-B), while using (2S)-1-(tert-butoxycarbonyl)-2-(1,2-epoxyethyl)pyrrolidine (2.00 g) and 4-fluorophenol (2.21 g), there was obtained 1.91 g of the title compound.

Sources & evidence

ORD record
ord-01c9e4151c1f4181b506ea2b9281ff31
Source dataset
uspto-grants-1996_04
Patent number
US05506256

Reaction notes

Loading…