HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diphosgene → (2S)-1-[N-(4-Chlorobenzylaminocarbonyl)-L-prolyl]-2-(1-hydroxy-2-phenoxyethyl)pyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diphosgene | HCID 10426 | — |
| Reactant | 4-Chlorobenzylamine | HCID 66036 | — |
| Reactant | (2S)-1-[N-(tert-Butoxycarbonyl)-L-prolyl]-2-(1-hydroxy-2-phenoxyethyl)pyrrolidine | HCID 70050944 | — |
| Product | (2S)-1-[N-(4-Chlorobenzylaminocarbonyl)-L-prolyl]-2-(1-hydroxy-2-phenoxyethyl)pyrrolidine | HCID 67771673 | 48.4% |
Reaction Steps
By the same procedure as in Example 28-B), while using 4-chlorobenzylamine (0.71 g), trichloromethyl chloroformate (0.3 ml) and (2S)-1-[N-(tert-butoxycarbonyl)-L-prolyl]-2-(1-hydroxy-2-phenoxyethyl)pyrrolidine (2.00 g), there was obtained 1.13 g of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05506256 |
| Source dataset | uspto-grants-1996_04 |
| ORD ID | ord-b1327d7cdcd14a29acefcd7dbf2ff3df |
| Source note | uspto-grants-1996_04 |