Benzyl isocyanate → HCID 67745436, compound

HRID 1720523Notes

Reaction equation

C(OC([N:8]1[CH2:30][CH2:29][CH2:28][C@H:9]1[C:10]([N:12]1[CH2:16][CH2:15][CH2:14][C@H:13]1[CH:17]([OH:27])[CH2:18][O:19][CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)=[O:11])=O)(C)(C)C.[CH2:31]([N:38]=[C:39]=[O:40])[C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1>>[CH2:31]([NH:38][C:39]([N:8]1[CH2:30][CH2:29][CH2:28][C@H:9]1[C:10]([N:12]1[CH2:16][CH2:15][CH2:14][C@H:13]1[CH:17]([OH:27])[CH2:18][O:19][CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)=[O:11])=[O:40])[C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1

Participants

Reactant 2

HCID 76639Benzyl isocyanate

HCID 67745458HCID 67745458, compound

Product 1

HCID 67745436HCID 67745436, compound

Procedure

By the same procedure as in Example 21-C), while using (2S)-1-[N-(tert-butoxycarbonyl)-L-prolyl]-2-(2-benzyloxy-1-hydroxyethyl)pyrrolidine (274 mg) and benzyl isocyanate (89 μl), there was obtained 243 mg of the title compound.

Sources & evidence

ORD record: ord-b797c2069e924419bdc0024490540f89
Source dataset: uspto-grants-1996_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05506256

Reaction notes

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