1,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (2S)- → HCID 86749403, compound

HRID 1720525Notes

Reaction equation

HRID 1720525 reaction equation
C(O[C:6]([N:8]1[CH2:12][CH2:11][CH2:10][C@H:9]1[CH:13]([OH:25])[CH2:14][O:15][C:16]1[CH:21]=[CH:20][C:19]2[O:22][CH2:23][O:24][C:18]=2[CH:17]=1)=[O:7])(C)(C)C.[C:26]([O:30][C:31]([N:33]1[CH2:40][CH2:39][CH2:38][C@H:34]1C(O)=O)=[O:32])([CH3:29])([CH3:28])[CH3:27]>>[C:26]([O:30][C:31]([N:33]1[CH2:40][CH2:39][CH2:38][C@H:34]1[C:6]([N:8]1[CH2:12][CH2:11][CH2:10][C@H:9]1[CH:13]([OH:25])[CH2:14][O:15][C:16]1[CH:21]=[CH:20][C:19]2[O:22][CH2:23][O:24][C:18]=2[CH:17]=1)=[O:7])=[O:32])([CH3:29])([CH3:27])[CH3:28]

Participants

3

Reactant 2

HCID 850831,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (2S)-HCID 57137063HCID 57137063, compound

Product 1

HCID 86749403HCID 86749403, compoundYield 68.1%

Procedure

By the same procedure as in Example 26-D), while using (2S)1-(tert-butoxycarbonyl)-2-{1-hydroxy-2-[(3,4-methylenedioxy)phenoxy]ethyl} pyrrolidine (2.38 g) and N-(tert-butoxycarbonyl)-L-proline (1.60 g), there was obtained 2.07 g of the title compound.

Sources & evidence

ORD record
ord-4b9a18aa4467487abd6bc56eb5eabcf6
Source dataset
uspto-grants-1996_04
Patent number
US05506256

Reaction notes

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