Benzyl isocyanate → HCID 22860050, compound

HRID 1720526Notes

Reaction equation

C([O:5][C:6]([N:8]1[CH2:32][CH2:31][CH2:30][C@H:9]1[C:10]([N:12]1[CH2:16][CH2:15][CH2:14][C@H:13]1[CH:17]([OH:29])[CH2:18][O:19][C:20]1[CH:25]=[CH:24][C:23]2[O:26][CH2:27][O:28][C:22]=2[CH:21]=1)=[O:11])=O)(C)(C)C.[CH2:33]([N:40]=C=O)[C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1>>[CH2:33]([NH:40][C:6]([N:8]1[CH2:32][CH2:31][CH2:30][C@H:9]1[C:10]([N:12]1[CH2:16][CH2:15][CH2:14][C@H:13]1[C:17](=[O:29])[CH2:18][O:19][C:20]1[CH:25]=[CH:24][C:23]2[O:26][CH2:27][O:28][C:22]=2[CH:21]=1)=[O:11])=[O:5])[C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1

Participants

Reactant 2

HCID 76639Benzyl isocyanate

HCID 86749403HCID 86749403, compound

Product 1

HCID 22860050HCID 22860050, compound

Procedure

By the same procedure as in Example 21-C), while using (2S)1-[N-(tert-butoxycarbonyl)-L-prolyl]-2-{1-hydroxy-2-[(3,4-methylenedioxy)phenoxy]ethyl} pyrrolidine (2.07 g) and benzyl isocyanate (0.63 ml), there was obtained 2.06 g of the title compound.

Sources & evidence

ORD record: ord-e8f4bb3d749b450f9452cb7bee2b9ff8
Source dataset: uspto-grants-1996_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05506256

Reaction notes

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