反应详情

To a solution of (2S)-1-(tert-butoxycarbonyl)-2-(1,2-epoxyethyl)pyrrolidine (1.50 g) in methanol (30 ml) were added phenol (1.50 g) and sodium methoxide (380 mg), and the mixture was stirred under reflux for 16 hours. The reaction mixture was concentrated, and the residue was dissolved in ether, washed with 10% citric acid, saturated aqueous sodium bicarbonate, and saturated brine successively, dried over anhydrous magnesium sulfate, and concentrated. The residue was purified by silica gel column chromatography (eluate: hexane-ethyl acetate) to give 1.10 g of the title compound.

1. temperatureunder reflux for 16 hours
2. concentrationThe reaction mixture was concentrated
3. dissolutionthe residue was dissolved in ether
4. washwashed with 10% citric acid, saturated aqueous sodium bicarbonate, and saturated brine successively
5. dry with materialdried over anhydrous magnesium sulfate
6. concentrationconcentrated
7. customThe residue was purified by silica gel column chromatography (eluate: hexane-ethyl acetate)