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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1720556Generated: October 31, 2026

Chlorotrimethylsilane → N2-Isobutyryl-2'-O-(imidazol-1-yl)butylguanosine

https://huagongshe.com/reaction/1720556

Reaction equation

Participants

RoleNameHCIDCharge
ReactantChlorotrimethylsilaneHCID 6397—
ReactantIsobutyryl chlorideHCID 62325—
Reactant2'-O-(Imidazol-1-yl)butylguanosineHCID 136079785—
SolventPyridineHCID 1049—
ProductN2-Isobutyryl-2'-O-(imidazol-1-yl)butylguanosineHCID 136132482—

Reaction Steps

2'-O-(imidazol-1-yl)butylguanosine in pyridine will be treated with trimethylsilyl chloride (5 eq) and isobutyryl chloride (5 eq) as per the procedure of Example 4 to yield the product.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05506351
Source datasetuspto-grants-1996_04
ORD IDord-0847bcad831247058ac2f90e4bf069dd
Source noteuspto-grants-1996_04