Methanol → HCID 88287593, compound

Participants

Reaction Steps

Methanol (2 ml) and a 50% aqueous solution of potassium hydroxide (0.07 g, 0.66 mmol) were added to (E)-2-(2-chloro-3-pyridyloxymethyl)-a-methoxyiminophenylacetonitrile (0.11 g, 0.33 mmol). The mixture was stirred under reflux for 6 hours. After completion of the reaction, water (100 ml) was added, and the resulting 10 mixture was washed with methylene chloride (50 ml). Hydrochloric acid (1N, 1 ml) was added, and the mixture was extracted with methylene chloride (50 ml) twice. The methylene chloride layer was dried over anhydrous magnesium sulfate and evaporated under reduced pressure to dryness to give (E)-2-(2-chloro-3-pyridyloxymethyl)-α-methoxyiminophenylacetic acid (0.05 g, 42.8 %) as colorless crystals.

Provenance & Evidence