HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyloxyamine hydrochloride → N-Benzyloxy-2(R)-[[4-methoxybenzenesulfonyl](3-picolyl)amino]-3-methylbutanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyloxyamine hydrochloride | HCID 102312 | — |
| Reactant | O-tert-butylhydroxylamine hydrochloride | HCID 2777906 | — |
| Reactant | 2(R)-[[4-methoxybenzenesulfonyl](3-picolyl)amino]-3-methyl-butanoic acid hydrochloride | HCID 70061703 | — |
| Product | N-Benzyloxy-2(R)-[[4-methoxybenzenesulfonyl](3-picolyl)amino]-3-methylbutanamide | HCID 22856293 | — |
Reaction Steps
The N-(benzyloxy) substituted prodrug derivative of the above compound is prepared as follows: 2(R)-[[4-methoxybenzenesulfonyl](3-picolyl)amino]-3-methylbutanoic acid hydrochloride is reacted with O-benzylhydroxylamine hydrochloride under conditions described for reaction with O-t-butylhydroxylamine hydrochloride to yield N-(benzyloxy)-2(R)-[[4-methoxybenzenesulfonyl](3-picolyl)amino]-3-methyl-butanamide, m.p. 74.5°-76° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05506242 |
| Source dataset | uspto-grants-1996_04 |
| ORD ID | ord-a8ab2795d56941fabd1c2e776924aa98 |
| Source note | uspto-grants-1996_04 |