1,4-Dioxane hydrochloride → HCID 22844601, compound

HRID 1720664Notes

Reaction equation

HRID 1720664 reaction equation
C(OC([NH:8][C@@H:9]([CH2:19][CH:20]([CH3:22])[CH3:21])[CH:10]([OH:18])[CH:11]([OH:17])[CH2:12][S:13][CH:14]([CH3:16])[CH3:15])=O)(C)(C)C.[ClH:23].O1CCOCC1>O1CCOCC1>[ClH:23].[NH2:8][C@@H:9]([CH2:19][CH:20]([CH3:22])[CH3:21])[CH:10]([OH:18])[CH:11]([OH:17])[CH2:12][S:13][CH:14]([CH3:15])[CH3:16]

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 22844609HCID 22844609, compound

Product 1

HCID 22844601HCID 22844601, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

21 mg of (2RS,3RS,4S)-4-(tert-butoxycarbonyl)amino-1-isopropylthio-6-methyl-2,3-heptanediol was dissolved in 0.3 ml of dioxane, and 0.32 ml of a 3.6M hydrogen chloride/dioxane solution was added thereto. The mixture was stirred at room temperature for 4 hours. The solvent was distilled off under reduced pressure from the reaction solution to obtain 16.9 mg of (2RS,3RS,4S)-4-amino-1-isopropylthio-6-methyl-2,3-heptanediol hydrochloride as colorless oily substance.

Workup

  1. distillationThe solvent was distilled off under reduced pressure from the reaction solution

Sources & evidence

ORD record
ord-f71f6c5b5e5c4489ae9157662e576c36
Source dataset
uspto-grants-1996_04
Patent number
US05506356

Reaction notes

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