HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → Caprine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | tert-butyl (2S)-2-aminohexanoate | HCID 12451446 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Caprine | HCID 21236 | — |
Reaction Steps
315 mg of L-N-[(2S or R)-3-(2-hydroxyethyl)sulfonyl-2-(1-naphthylmethyl)propionyl]norleucine tert-butyl ester was dissolved in 2 ml of dry dichloromethane, and 1 ml of TFA was added thereto. The mixture was stirred at room temperature for three hours. The solvent was distilled off. The residue was recrystallized from ethyl acetate to obtain 267 mg of L-N-[(2S or R)-3-(2-hydroxyethyl)sulfonyl-2-(1-naphthylmethyl)propionyl]norleucine as colorless solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05506356 |
| Source dataset | uspto-grants-1996_04 |
| ORD ID | ord-ba75ddab43ef4c088182253c8787a13f |
| Source note | uspto-grants-1996_04 |