HCID 15708223, compound → HCID 11805344, compound

HRID 1720687Notes

Reaction equation

HRID 1720687 reaction equation
[CH2:1]([C@H:8]([CH2:12][O:13]CC1C=CC=CC=1)[C:9]([OH:11])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C(O)C.[Pd]>[CH2:1]([C@H:8]([CH2:12][OH:13])[C:9]([OH:11])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 1

HCID 15708223HCID 15708223, compound

Product 1

HCID 11805344HCID 11805344, compoundYield 103.6%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

420 mg of (2R)-2-benzyl-3-benzyloxypropionic acid was dissolved in 5.5 ml of ethanol, and hydrogenated at an ordinary temperature under an atmospheric pressure for two hours in the presence of palladium black. The insolubles were removed by filtration, and then the solvent was distilled off under reduced pressure to obtain 290 mg of (2R)-2-benzyl-3-hydroxypropionic acid as colorless oily substance.

Workup

  1. customThe insolubles were removed by filtration
  2. distillationthe solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-6d788f4cee4d4d80afa45cdb2dfa97f3
Source dataset
uspto-grants-1996_04
Patent number
US05506356

Reaction notes

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