2-Chloropyridine → HCID 22418741, compound

HRID 1720754Notes

Reaction equation

HRID 1720754 reaction equation
[CH3:1][NH:2][CH2:3][CH2:4][NH:5][CH3:6].Cl[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][N:9]=1>>[CH3:1][NH:2][CH2:3][CH2:4][N:5]([CH3:6])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][N:9]=1

Participants

3

Reactant 2

HCID 79772-ChloropyridineHCID 8070N,N'-Dimethylethylenediamine

Product 1

HCID 22418741HCID 22418741, compound

Procedure

A mixture of N,N'-dimethylethylene-diamine (25 g) and 2-chloropyridine (1.3 g) is warmed at 85° with stirring for 18 h. The excess dimethylethylenediamine is removed by distillation at reduced pressure. The distillation residue is distributed between ethyl acetate (150 ml) and water (100 ml). The organic phase is separated, dried over sodium sulfate and the organic solvent removed under reduced pressure to give the title compound.

Workup

  1. temperatureis warmed at 85°
  2. customThe excess dimethylethylenediamine is removed by distillation at reduced pressure
  3. customThe organic phase is separated
  4. dry with materialdried over sodium sulfate
  5. customthe organic solvent removed under reduced pressure

Sources & evidence

ORD record
ord-d04e96ecd83f46148a56efae8e4ee3c2
Source dataset
uspto-grants-1996_04
Patent number
US05506354

Reaction notes

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