Palmitoyl chloride → HCID 53712566, compound

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Reaction Steps

A solution of 6-hydroxy-7-octadecylcarbamoyloxy-4-thiaheptanoic acid t-butyl ester as obtained in Reference Example 7 (2.98 g), dimethylaminopyridine (820 mg) and palmitoyl chloride (1.54 g) in dichloromethane (10 ml) was stirred at room temperature for 30 minutes, followed by solvent concentration under reduced pressure. The residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=10:1) to yield the title compound (3.425 g, yield 79%) as a colorless wax-like substance.

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