Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diethyl Pyrocarbonate → HCID 10768458, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diethyl Pyrocarbonate | HCID 3051 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Di-tert-butyl glutamate hydrochloride | HCID 208636 | — |
| 반응물 | 4-((((Benzyloxy)carbonyl)amino)methyl)benzoic acid | HCID 1479997 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | HCID 10768458 | HCID 10768458 | 100% |
반응 단계
To a solution of 4-(benzyloxycarbonylaminomethyl)benzoic acid as obtained in Reference Example 35 (1.0 g), glutamic acid di-t-butyl ester hydrochloride (1.15 g) and DEPC (860 mg) in dimethylformamide (20 ml), triethylamine (1.06 g) was added drop by drop, followed by stirring at room temperature for 1 hour. After solvent concentration under reduced pressure, the resulting residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=2:1) to yield the title compound (1.86 g, yield 100%) as a colorless wax-like substance.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05506267 |
| 출처 데이터셋 | uspto-grants-1996_04 |
| ORD ID | ord-7e4da600b05d4c14bdc78ee3eef87aa7 |
| 출처 메모 | uspto-grants-1996_04 |