HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → 4-[6,7-Bis(octadecylcarbamoyloxy)-4thiaheptanoylamino]benzoylglutamic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | 4-[6,7-Bis(octadecylcarbamoyloxy)-4-thiaheptanoylamino]benzoyl-glutamic acid di-t-butyl ester | HCID 10748770 | — |
| Solvent | Trifluoroacetic acid | HCID 6422 | — |
| Product | 4-[6,7-Bis(octadecylcarbamoyloxy)-4thiaheptanoylamino]benzoylglutamic acid | HCID 10629857 | 100% |
Reaction Steps
A solution of 4-[6,7-bis(octadecylcarbamoyloxy)-4-thiaheptanoylamino]benzoyl-glutamic acid di-t-butyl ester as obtained in Example 31 (100 mg) in trifiuoroacetic acid (2 ml)-dichloromethane (0.5 ml) was stirred at room temperature for 1 hour. After solvent concentration under reduced pressure, the resulting residue was crystallized from chloroform-methanolwater to yield the title compound (99 mg, yield 100%) as a colorless powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05506267 |
| Source dataset | uspto-grants-1996_04 |
| ORD ID | ord-2d01af0cf279447b995f321423b24518 |
| Source note | uspto-grants-1996_04 |