HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus trichloride → HCID 54427159, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus trichloride | HCID 24387 | — |
| Reactant | Benzoic acid, 4-amino-, 1,1-dimethylethyl ester | HCID 233272 | — |
| Reactant | 6,7-Bis(palmitoyloxy)-4-thiaheptanoic acid | HCID 10556278 | — |
| Reactant | HCID 10843463 | HCID 10843463 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | HCID 54427159 | HCID 54427159 | 99% |
Reaction Steps
A solution of 6,7-bis(palmitoyloxy)-4-thiaheptanoic acid as obtained in Reference Example 4 (2.0 g), 4-aminobenzoic acid t-butyl ester (600 mg) and phosphorus trichloride (207 mg) in pyridine (40 ml) was stirred at room temperature for 30 minutes. After solvent concentration under reduced pressure, the resulting residue was purified by silica gel column chromatography (chloroform) to yield the title compound (2.157 g, yield 99%) as a colorless solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05506267 |
| Source dataset | uspto-grants-1996_04 |
| ORD ID | ord-4d8ebfcb91b14eda814eac9ef3b57675 |
| Source note | uspto-grants-1996_04 |