4-(6,7-Bis(palmitoyloxy)-4-thiaheptanoyl)amino-2-fluorobenzoylglutamic acid di-t-butyl ester → 4-(6,7-Bis(palmitoyloxy)-4-thiaheptanoyl)amino-2-fiuorobenzoylglutamic acid

HRID 1720827노트

반응식

HRID 1720827 반응식
C([O:5][C:6](=[O:72])[C@H:7]([CH2:63][CH2:64][C:65]([O:67]C(C)(C)C)=[O:66])[NH:8][C:9](=[O:62])[C:10]1[CH:15]=[CH:14][C:13]([NH:16][C:17](=[O:60])[CH2:18][CH2:19][S:20][CH2:21][CH:22]([O:42][C:43](=[O:59])[CH2:44][CH2:45][CH2:46][CH2:47][CH2:48][CH2:49][CH2:50][CH2:51][CH2:52][CH2:53][CH2:54][CH2:55][CH2:56][CH2:57][CH3:58])[CH2:23][O:24][C:25](=[O:41])[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH3:40])=[CH:12][C:11]=1[F:61])(C)(C)C>FC(F)(F)C(O)=O>[C:43]([O:42][CH:22]([CH2:23][O:24][C:25](=[O:41])[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH3:40])[CH2:21][S:20][CH2:19][CH2:18][C:17]([NH:16][C:13]1[CH:14]=[CH:15][C:10]([C:9]([NH:8][C@H:7]([C:6]([OH:72])=[O:5])[CH2:63][CH2:64][C:65]([OH:67])=[O:66])=[O:62])=[C:11]([F:61])[CH:12]=1)=[O:60])(=[O:59])[CH2:44][CH2:45][CH2:46][CH2:47][CH2:48][CH2:49][CH2:50][CH2:51][CH2:52][CH2:53][CH2:54][CH2:55][CH2:56][CH2:57][CH3:58]

참가 물질

3

반응물 1

HCID 537823564-(6,7-Bis(palmitoyloxy)-4-thiaheptanoyl)amino-2-fluorobenzoylglutamic acid di-t-butyl ester

생성물 1

HCID 539912654-(6,7-Bis(palmitoyloxy)-4-thiaheptanoyl)amino-2-fiuorobenzoylglutamic acid수율 100%

시약·촉매·용매 1

HCID 6422Trifluoroacetic acid용매

실험 절차

A solution of 4-(6,7-bis(palmitoyloxy)-4-thiaheptanoyl)amino-2-fluorobenzoylglutamic acid di-t-butyl ester as obtained in Example 50 (205 mg) in trifiuoroacetic acid (5 ml) was stirred at room temperature for 4 hours, followed by concentration, to yield the title compound (183 mg, yield 100%) as a colorless crystal.

후처리

  1. concentrationfollowed by concentration

출처 및 근거

ORD 기록
ord-8513652e3d76485f8dd408b4b34ed06a
출처 데이터셋
uspto-grants-1996_04
특허 번호
US05506267

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