Phenol → Diglycidyl ether

Participants

Reaction Steps

2.50 g of a phenol derivative represented by the following formula: ##STR17## 4.25 g of R-(-)-epichlorohydrin (chemical purity: 98.5% or more, optical purity: 99% or more) and 20 mg of benzyltriethylammonium chrolide were dissolved in 3 ml of dimethylformamide. To the solution was added dropwise 24% by weight sodium hydroxide aqueous solution (1.2 equivalents) at 60° C. The reaction was conducted for 40 minutes at the same temperature, and then the reaction mixture was cooled to room temperature followed by extraction with ether. After evaporating the solvent at reduced pressure, the residue was purified by a silica gel column chromatography to obtain 1.62 g of a S-isomer of glycidyl ether represented by the following formula (Intermediate 1). ##STR18##

Provenance & Evidence