Methanol → HCID 1898172, compound

Participants

Reaction Steps

To a mixture of 10.0 g (32.4 mmol) of 3,5-di-tertiary-butyl-4-hydroxybenzenesulfonyl chloride, prepared as described above, and 50 ml of anhydrous methanol was added 2.56 g (32.4 mmol) of pyridine. An exothermic reaction ensued resulting in a solution. The solution was stirred at room temperature for 30 minutes and poured into water. A white solid precipitate formed which was collected and dissolved in methylene chloride. The solution was washed with water, dried over magnesium sulfate and concentrated. The solid residue was recrystallized from heptane to give 7.66 g of, as a white crystalline product, methyl 3,5-di-tertiary-butyl-4-hydroxybenzenesulfonate (78.7% of theory); mp=116.5°-18° C.

Provenance & Evidence