HCID 15341134, compound → HCID 22416495, compound

Participants

Reaction Conditions

Reaction Steps

O,O-Diethyl bis(3-trifluoromethylphenyl)methylphosphonate (6.12 g, 13.9 mmol) was dissolved in ethanol (220 mL) and 118 mL of concentrated hydrochloric acid. The resulting solution was heated at 95° C. for 66 hours. The mixture was concentrated in volume and a precipitate formed. The solid was filtered, washed with H2O (3×20 mL), and dried to give 3.60 g (67.4%)of analytically pure product as a white solid, mp 191°-193° C. 300 MHz 1H NMR (DMSO-d6): δ,4.78 (d,1H, J=23.4 Hz, PCH). MS: 385 (M+1).

Provenance & Evidence