5H-Dibenzo[a,d]cyclohepten-5-one → HCID 15818605, compound

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Reaction Steps

To 150 mmol of ethyl magnesium bromide in 150 ml of ether are added 10 g (48.5 mmol) of dibenzosuberenone in 250 ml of ether at 0° C. After 3 hours at about 10° C., the mixture is cooled in an ice bath and 40 ml of saturated aqueous ammonium chloride are added slowly. Extractions of the aqueous phase with ether affords 10.75 g of a yellow oily residue. Purification by flash chromatography yields 8.5 g (74%) of the expected product.

Provenance & Evidence