Acetyl chloride → HCID 22416519, compound

Participants

Reaction Conditions

Reaction Steps

8.5 g of 5-ethyl-5H-dibenzo[a,d]cycloheptene-5-ol are dissolved in 70 ml of glacial acetic acid and 14 ml of acetyl chloride and the mixture is stirred and warmed at 95° C. overnight. Evaporation to dryness leads to a red oily residue which is dissolved in ethyl acetate, washed with water and dried on sodium sulfate. Evaporation affords 8.26 g of a crude oil which is purified by flash chromatography (cyclohexane) yielding 8.27 g (78%) of the pure title compound. A 96.5% yield can be obtained with a 3 days reaction time.

Provenance & Evidence