HuagongsheHuagongshe Chemistry Print Report · For research reference only
1H-Indole, 1-methyl-5-nitro- → 1-methyl-1H-indol-5-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1H-Indole, 1-methyl-5-nitro- | HCID 147322 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-methyl-1H-indol-5-amine | HCID 2769564 | 95% |
Reaction Steps
A mixture of the nitroindole (D1) (5 g; 28.4 mmol) and 5% palladium on charcoal in ethanol (300 ml) was hydrogenated at 60 p.s.i. (4.14×105Pa) at room temperature for 3 h. Removal of the catalyst by filtration followed by evaporation of the solvent gave the title compound (3.39 g, 95%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05508288 |
| Source dataset | uspto-grants-1996_04 |
| ORD ID | ord-ee2350dba4f848709c2bb503acd378bb |
| Source note | uspto-grants-1996_04 |