HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → N-(1-Methyl-5-indolyl)-N'-(4-isoquinolyl) urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| Reactant | 4-Aminoisoquinoline | HCID 90237 | — |
| Reactant | 1-methyl-1H-indol-5-amine | HCID 2769564 | — |
| Solvent | Diethyl ether ethanol | HCID 21585056 | — |
| Product | N-(1-Methyl-5-indolyl)-N'-(4-isoquinolyl) urea | HCID 22416532 | — |
Reaction Steps
The title compound was prepared from 4-aminoisoquinoline, 1,1'-carbonyl diimidazole and 5-amino-1-methyl-indole using a procedure similar to that described for Example 1, and then converted to the hydrochloride salt using hydrogen chloride in ether/ethanol, in 26% overall yield, m.p. 195°-197° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05508288 |
| Source dataset | uspto-grants-1996_04 |
| ORD ID | ord-215ab40df9634630af5f9a7d20aca993 |
| Source note | uspto-grants-1996_04 |