Cyanamide → HCID 10241976, compound

HRID 1720900Notes

Reaction equation

HRID 1720900 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([C:8](=[NH:13])[O:9][CH2:10][CH2:11][CH3:12])[CH:5]=[N:6][CH:7]=1.[N:14]#[C:15]N>>[C:15]([N:13]=[C:8]([C:4]1[CH:5]=[N:6][CH:7]=[C:2]([CH3:1])[CH:3]=1)[O:9][CH2:10][CH2:11][CH3:12])#[N:14]

Participants

3

Reactant 2

HCID 9864CyanamideHCID 10329892HCID 10329892, compound

Product 1

HCID 10241976HCID 10241976, compound

Procedure

To propyl 5-methyl-3-pyridinecarboximidate was then added an aqueous solution (100 ml) of cyanamide (1.42 g, 33.8 mmol), Na2HPO4 (2.40 g, 16.9 mmol) and NaH2PO4 ·2H2O (10.56 g, 67.7 mmol). The mixture was stirred at room temperature for 5 hours and extracted with chloroform (100 ml×3). The chloroform layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to give a crude product of propyl N-cyano-5-methyl-3-pyridinecarboximidate (2.54 g). IR (neat) cm-1 : 2200, 1610, 1320, 730.

Workup

  1. extractionextracted with chloroform (100 ml×3)
  2. dry with materialThe chloroform layer was dried over anhydrous sodium sulfate
  3. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-3ee806ad00ad4694bdaefcc20e72927a
Source dataset
uspto-grants-1996_04
Patent number
US05508293

Reaction notes

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