5-Ethynylnicotinonitrile → 5-Ethylnicotinonitrile

Participants

Reaction Steps

3-Cyano-5-ethynylpyridine (1 g) was dissolved in tetrahydrofuran (30 ml) and subjected to catalytic hydrogenation under hydrogen stream in the presence of 10% palladium-carbon (100 mg) as a catalyst. After the catalyst was removed by filtration, the filtrate was concentrated under reduced pressure to give 0.87 g of 3-cyano-5-ethylpyridine (yield, 84%). 1H-NMR (90 MHz, CDCl3): δ (ppm) 8.58(1H, H-2), 8.39(1H, H-6), 7.77(1H, H-4), 2.72(2H, q, J=7.5Hz, Pyridine-CH2CH3), 1.26(3H, t, J=7.5Hz, Pyridine-CH2CH3).

Provenance & Evidence