反应详情

To a solution of propyl 5-n-butylamino-N-cyano-3-pyridinecarboximidate (99 mg, 0.38 mmol) in methanol (2 ml) was added 2-(2-chlorophenyl)ethylamine (71 mg, 0.46 mmol), and the mixture was stirred for 2 hours. After the reaction was completed, the reaction mixture was concentrated under reduced pressure and the residue obtained was purified by silica gel column chromatography (Wako Gel C-200, 30 g; eluted with chloroform:methanol=200:1) and further crystallized from diethyl ether to give the title compound (90 mg, 0.25 mmol) as colorless crystals in the yield of 67%.

1. concentrationthe reaction mixture was concentrated under reduced pressure
2. customthe residue obtained
3. customwas purified by silica gel column chromatography (Wako Gel C-200, 30 g; eluted with chloroform:methanol=200:1)
4. customfurther crystallized from diethyl ether