2-(2-Chlorophenyl)ethylamine → HCID 10475477, compound

Participants

Reaction Steps

To a solution of propyl 5-benzylamino-N-cyano-3-pyridinecarboximidate (114 mg, 0.38 mmol) in methanol (2 ml) was added 2-(2-chlorophenyl)ethylamine (72 mg, 0.46 mmol), and the mixture was stirred for 105 minutes. After the reaction was completed, the reaction mixture was concentrated under reduced pressure and the residue obtained was purified by silica gel column chromatography (Wako Gel C-200, 20 g; eluted with chloroform:methanol=200:1) and further crystallized from diethyl ether to give the title compound (126 mg, 0.32 mmol) as colorless crystals in the yield of 85%.

Provenance & Evidence