Methanesulfonic Acid → HCID 10339590, compound

Participants

Reaction Steps

To a solution of 5-amino-N-cyano-N'-[2-(2-chlorophenyl)ethyl]-3-pyridinecarboximidamide (110 mg, 0.39 mmol) in pyridine (2 ml) was added anhydrous methanesulfonic acid (65 mg, 0.37 mmol), and the mixture was stirred at room temperature for 5 hours. After the reaction was completed, ice and a saturated aqueous sodium carbonate solution (20 ml) were added to the reaction mixture, and the mixture was extracted with ethyl acetate (30 ml×3). The ethyl acetate layer was washed with saturated brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue obtained was subjected to silica gel column chromatography (Wako Gel C-200, 20 g) and eluted with chloroform:methanol (50:1) to give the title compound (45 mg, yield 32%) as colorless powder.

Provenance & Evidence