HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diketene → 3-(4,4-Diphenylpiperid-1-yl)-propyl acetoacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diketene | HCID 12661 | — |
| Reactant | 4,4-Diphenyl-1-piperidinepropanol | HCID 10402259 | — |
| Solvent | Acetone | HCID 180 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 3-(4,4-Diphenylpiperid-1-yl)-propyl acetoacetate | HCID 9977017 | — |
Reaction Steps
23.6 g of 3-(4,4-diphenylpiperid-1-yl)-propanol was dissolved in 100 ml of absolute toluene, and 16 ml of a 50% strength solution of diketene in acetone was added with stirring. After standing for several days at room temperature (monitored by thin layer chromatography), the mixture was concentrated, and the residue was dried under high vacuum. The pale yellow, viscous oil which remains was employed without further purification for the next stage.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05508306 |
| Source dataset | uspto-grants-1996_04 |
| ORD ID | ord-01db4c49e6a04fb0a34e3d6957777204 |
| Source note | uspto-grants-1996_04 |