HCID 178418361, compound → HCID 178450990, compound

HRID 1720998Notes

Reaction equation

HRID 1720998 reaction equation
[ClH:1].[CH2:2]([O:6][CH:7]([O:31][CH2:32][CH2:33][CH2:34][CH3:35])[C@H:8]([CH2:24][CH2:25][CH2:26][NH:27][C:28](=[NH:30])[NH2:29])[NH:9][C:10](=[O:23])[CH2:11][NH:12]C(OCC1C=CC=CC=1)=O)[CH2:3][CH2:4][CH3:5].[H][H]>CO.[Pd]>[ClH:1].[CH2:32]([O:31][CH:7]([O:6][CH2:2][CH2:3][CH2:4][CH3:5])[C@H:8]([CH2:24][CH2:25][CH2:26][NH:27][C:28](=[NH:29])[NH2:30])[NH:9][C:10](=[O:23])[CH2:11][NH2:12])[CH2:33][CH2:34][CH3:35]

Participants

5

Reactant 2

HCID 178418361HCID 178418361, compoundHCID 178450992HCID 178450992, compound

Product 1

HCID 178450990HCID 178450990, compoundYield 101.3%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

After N-benzyloxycarbonyl-glycyl-L-argininal dibutylacetal hydrochloride (1.60 g, 3.10 mmols) was dissolved in methanol (250 ml), palladium black (1 g) was added to the solution. The mixture was stirred at room temperature for 2 hours in a hydrogen flow. After completion of the reaction, the catalyst was filtered off and the filtrate was concentrated to give 1.20 g (100%) of glycyl-L-argininal dibutylacetal hydrochloride as oil.

Workup

  1. customAfter completion of the reaction
  2. filtrationthe catalyst was filtered off
  3. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-c4400252edf948d5b37f2817ff8221f1
Source dataset
uspto-grants-1996_04
Patent number
US05508385

Reaction notes

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