Sulfuric Acid → HCID 178512838, compound

Participants

Reaction Steps

To a solution of N-benzyloxycarbonyl-L-pyroglutamyl-L-prolyl-L-argininal dibutylacetal 1/2 sulfate (0.61 g, 0.90 mmol) in acetonitrile (90 ml) was added 1N sulfuric acid aqueous solution (45 ml). The mixture was reacted at 36° C. for 4 hours with stirring. After completion of the reaction, pH of the reaction mixture was adjusted to 5.6 with 1N sodium hydroxide aqueous solution. The solvent was distilled off under reduced pressure and chloroform was added to the residue. Insoluble matters were filtered off. After the filtrate was concentrated, the residue was recrystallized from chloroform-hexane to give 0.43 g (87%) of N-benzyloxycarbonyl-L-pyroglutamyl-L-prolyl-L-argininal.1/2 sulfate.

Provenance & Evidence