HCID 178418361, compound → HCID 178512837, compound

Participants

Reaction Steps

After N-benzyloxycarbonyl-L-pyroglutamyl-L-prolyl-L-argininal 1/2 sulfate (0.055 g, 0.10 mmol) was dissolved in 85% methanol (25 ml), a small amount of palladium black (1 g) was added to the solution followed by catalytic hydrogenation at room temperature for an hour in a hydrogen flow. After completion of the reaction, the catalyst was filtered off and the filtrate was concentrated. The residue was dissolved in a small amount of methanol and the solution was poured onto an excess of dry ether. The precipitated crystals were filtered to give 0.032 g (77%) of L-pyroglutamyl-L-prolyl-L-argininal.1/2 sulfate.

Provenance & Evidence