Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | cis-1,2-Indandiol | HCID 20758 | — |
| Product | (1R,2S)-(+)-cis-1-Amino-2-indanol | HCID 2725045 | — |
Reaction Steps
Cis-1,2-indandiol (1.0 g) was dissolved in acetonitrile (20 mL), cooled to -40° C., and fuming sulfuric acid (21% SO3, 0.8 mL) was added. The mixture was aged for 1 hour with gradual warming to 0° C. Water was added and the mixture heated to 80° C. for 1 hour to provide an aqueous solution of cis-1-amino-2-indanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05508404 |
|---|
| Source dataset | uspto-grants-1996_04 |
|---|
| ORD ID | ord-3fdd7f46a1c344f8ba3f4c44a54986b7 |
|---|
| Source note | uspto-grants-1996_04 |
|---|
