反应详情

温度

90 °C

Combine (S)-3-phenyllactic acid (11.17 g, 67.2 mmol) and sulfuric acid (0.3 mL of a 10% solution in acetic acid). Add acetic anhydride (6.34 mL, 67.2 mmol) over 10 minutes. Warm to 90° C. with stirring for 45 minutes. Allow to cool, pour into diethyl ether and extract with water three times. Separate the organic layer, dry (MgSO4) and concentrate in vacuo to yield (S)-3-phenyl-2-acetyloxypropionic acid as a white oil.

1. temperatureAllow to cool
2. extractionextract with water three times
3. customSeparate the organic layer
4. dry with materialdry (MgSO4)
5. concentrationconcentrate in vacuo