HRID17211

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID176

Acetic Acid

C2H4O2

结构：COc1cc(-c2csc3c(C(=O)NCC4CCCCN4)cnc(N)c23)ccc1NC(=O)c1cc2ccccc2n1C

HCID18450822

未命名化合物

PRODUCTS

生成物

结构：COc1cc(-c2csc3c(C(=O)NCC4CCCCN4C(C)=O)cnc(N)c23)ccc1NC(=O)c1cc2ccccc2n1C

HCID18450890

未命名化合物

PROCEDURE

实验过程

4-Amino-3-(3-methoxy-4-{[(1-methyl-1H-indol-2-yl)carbonyl]amino}phenyl)-N-(piperidin-2-ylmethyl)thieno[3,2-c]pyridine-7-carboxamide (0.090 g, 0.16 mmol) and acetic acid (0.012 g, 0.17 mmol) were treated according to General Procedure D to provide the title compound. LCMS Conditions a: 3.11 minute, 611.1 (MH+).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-83fd7a10038541078a9db084ee70b21a
来源数据集: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07737160B2
来源说明: uspto-grants-2010_06

反应 SMILES

[NH2:1][C:2]1[C:7]2[C:8]([C:11]3[CH:16]=[CH:15][C:14]([NH:17][C:18]([C:20]4[N:21]([CH3:29])[C:22]5[C:27]([CH:28]=4)=[CH:26][CH:25]=[CH:24][CH:23]=5)=[O:19])=[C:13]([O:30][CH3:31])[CH:12]=3)=[CH:9][S:10][C:6]=2[C:5]([C:32]([NH:34][CH2:35][CH:36]2[CH2:41][CH2:40][CH2:39][CH2:38][NH:37]2)=[O:33])=[CH:4][N:3]=1.[C:42](O)(=[O:44])[CH3:43]>>[C:42]([N:37]1[CH2:38][CH2:39][CH2:40][CH2:41][CH:36]1[CH2:35][NH:34][C:32]([C:5]1[C:6]2[S:10][CH:9]=[C:8]([C:11]3[CH:16]=[CH:15][C:14]([NH:17][C:18]([C:20]4[N:21]([CH3:29])[C:22]5[C:27]([CH:28]=4)=[CH:26][CH:25]=[CH:24][CH:23]=5)=[O:19])=[C:13]([O:30][CH3:31])[CH:12]=3)[C:7]=2[C:2]([NH2:1])=[N:3][CH:4]=1)=[O:33])(=[O:44])[CH3:43]