Potassium Iodide → HCID 22416860, compound

Participants

Reaction Steps

3-(8-fluoro-2-quinolinylmethoxy)nitrobenzene: 0.67 g of 3-nitrophenol and 1.15 g of 2-bromomethyl-8-fluoroquinoline are dissolved in 110 ml of ethyl methyl ketone; 3.3 g of potassium carbonate and 0.8 g of potassium iodide are added and the batch is heated under reflux for 3 hours. After cooling, removing the solid by filtration and evaporating the solvent in vacuo, 100 ml of dichloromethane are added to the residue, the batch is washed with water (twice, 20 ml each time), dried over sodium sulfate, filtered and freed of the solvent in vacuo to give the title compound in the form of pale yellow crystals of m.p. 128°-129° after recrystallisation from dichloromethane/hexane.

Provenance & Evidence