反应详情

2 g of 3-(7-bromo-2-quinolinylmethoxy)aniline and 1.9 g of 2,2-diethylsuccinic acid anhydride (purified by distillation) are stirred in 28 ml of pyridine for 72 hours at 20° and concentrated by evaporation. The residue is suspended in 25 ml of 2N aqueous hydrochloric acid and the suspension is stirred for 30 min. at 20° and filtered. The precipitate is washed with water and crystallised from ethanol to give the title compound in the form of colourless crystals of m.p. 175°, IR (Nujol): inter alia 3600-2100, 3308, 1710, 1670, 1610, 1600, 1497 cm-1.

1. concentrationconcentrated by evaporation
2. filtrationfiltered
3. washThe precipitate is washed with water
4. customcrystallised from ethanol