Ethyl Acetate → HCID 22416898, compound

Participants

Reaction Steps

3-(7-trifluoromethoxy-2-quinolinylmethoxy)aniline: 0.175 g of NaH (95%) is added at 0° to a solution of 0.754 g of 3-aminophenol in 20 ml of DMF and then the batch is stirred for 30 min. at 0°. 1.78 g of 2-chloromethyl-7-trifluoromethoxy-quinoline in solid form are then added and the batch is stirred for a further one hour at 0° and for another hour at 20°. It is then diluted with ethyl acetate, washed with water, dried over Na2SO4 and concentrated by evaporation. The evaporation residue is chromatographed on 100 g of silica gel. The product-containing fractions eluted with toluene/ethyl acetate 98:2 and 95:5 are combined and concentrated by evaporation to give the title compound which is further purified by crystallisation from CH2Cl2 /ether/hexane.

Provenance & Evidence