Dihydro-3,3-diethyl-2,5-furandione → 4-[3-(6-Methyl-2-quinolinylmethoxy)phenylamino]-2,2-diethyl-4-oxobutanoic acid

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Reaction Steps

2.05 g of 3-(6-methyl-2-quinolinylmethoxy)aniline and 2.42 g of 2,2-diethylsuccinic acid anhydride are stirred in 30 ml of pyridine for 72 hours at 20° and concentrated by evaporation. The residue is suspended in 25 ml of 2N aqueous hydrochloric acid and the suspension is stirred for 30 min. at 20° and filtered. The precipitate is washed with water and crystallised from ethanol to give the title compound in the form of crystals of m.p. 175°, IR (Nujol): inter alia 3600-2600, 3320, 1685, 1545 cm-1.

Provenance & Evidence