Ethyl Acetate → HCID 22416930, compound

Participants

Reaction Steps

3-(6,7-dimethyl-2-quinolinylmethoxy)aniline: 0.35 g of NaH (95%) is added at 0° to a solution of 1.51 g of 3-aminophenol in 30 ml of DMF and then the batch is stirred for 30 min. at 0°. 2.8 g of 2-chloromethyl-6,7-dimethyl-quinoline in solid form are then added and the batch is stirred for a further one hour at 0° and for another hour at 20°. It is then diluted with ethyl acetate, washed with water, dried over Na2SO4 and concentrated by evaporation. The evaporation residue is chromatographed on 250 g of silica gel. The product-containing fractions eluted with toluene/ethyl acetate 95:5 and 9:1 are combined and concentrated by evaporation to give the title compound which is further purified by crystallisation from CH2Cl2 /ether.

Provenance & Evidence