3-(7-Fluoro-2-quinolinylmethoxy)aniline → 4-[3-(7-Fluoro-2-quinolinylmethoxy)phenylamino]-2,2-dipropyl-4-oxobutanoic acid

HRID 1721189Notes

Reaction equation

HRID 1721189 reaction equation
[CH2:1]([C:4]1([CH2:11][CH2:12][CH3:13])[CH2:9][C:8](=[O:10])[O:7][C:5]1=[O:6])[CH2:2][CH3:3].[F:14][C:15]1[CH:24]=[C:23]2[C:18]([CH:19]=[CH:20][C:21]([CH2:25][O:26][C:27]3[CH:28]=[C:29]([CH:31]=[CH:32][CH:33]=3)[NH2:30])=[N:22]2)=[CH:17][CH:16]=1>>[F:14][C:15]1[CH:24]=[C:23]2[C:18]([CH:19]=[CH:20][C:21]([CH2:25][O:26][C:27]3[CH:28]=[C:29]([NH:30][C:8](=[O:10])[CH2:9][C:4]([CH2:11][CH2:12][CH3:13])([CH2:1][CH2:2][CH3:3])[C:5]([OH:7])=[O:6])[CH:31]=[CH:32][CH:33]=3)=[N:22]2)=[CH:17][CH:16]=1

Participants

3

Reactant 2

HCID 224168723-(7-Fluoro-2-quinolinylmethoxy)anilineHCID 431348873,3-Dipropyldihydrofuran-2,5-dione

Product 1

HCID 224168734-[3-(7-Fluoro-2-quinolinylmethoxy)phenylamino]-2,2-dipropyl-4-oxobutanoic acid

Procedure

The title compound is prepared analogously to the compound described in Example 20 from 2,2-dipropylsuccinic acid anhydride and 3-(7-fluoro-2-quinolinylmethoxy)aniline; beige crystals of m.p. 155°-156°.

Sources & evidence

ORD record
ord-5c6d46f301524830b20db1cdafe21037
Source dataset
uspto-grants-1996_04
Patent number
US05508408

Reaction notes

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